Staff/Senior Machine Learning Engineer, Clinical AI
Tempus · Chicago, IL
About this role
Tempus is hiring a senior-level Machine Learning Engineer based in Chicago, IL. The posting calls out experience with Python, GCP, Airflow, PyTorch. Compensation is listed at $170,000–$230,000 per year.
- Role
- Machine Learning Engineer
- Function
- machine learning
- Level
- senior
- Track
- Tech leadership
- Employment
- Full-time
- Location
- Chicago, IL
- Posted
- May 15, 2026
More roles at Tempus
Job description
from Tempus careersPassionate about precision medicine and advancing the healthcare industry?
Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time.
We're seeking a highly skilled and innovative Staff/Senior Machine Learning Engineer to join our Clinical AI Team. As a Staff/Senior Machine Learning Engineer, you'll play a crucial role in leveraging and deploying cutting-edge natural language processing models and LLMs specifically tailored for healthcare applications at scale. Your work will contribute to optimizing clinical workflows, improving clinical trial matching, and advancing medical research. This position offers an exciting opportunity to leverage the power of natural language processing and LLMs to revolutionize healthcare and make a significant impact on people's lives.
What You Will Do:
Build and operate production AI pipelines: LLM-powered extraction, batch orchestration, and inference, with a focus on reliability, cost, and latency
Design and maintain Airflow-based orchestration for batch clinical workflows
Build the observability (metrics, logging, alerting) that catches regressions before they reach downstream consumers
Build and maintain eval infrastructure that measures clinical model output quality continuously: regression detection, drift, gold-set management, dashboards
This is an excerpt. Read the full job description on Tempus careers →