senior Machine Learning Engineer tech_leadership · Posted May 15, 2026
$170,000 – $230,000
USD per year

About this role

Tempus is hiring a senior-level Machine Learning Engineer based in Chicago, IL. The posting calls out experience with Python, GCP, Airflow, PyTorch. Compensation is listed at $170,000–$230,000 per year.

Role
Machine Learning Engineer
Function
machine learning
Level
senior
Track
Tech leadership
Employment
Full-time
Location
Chicago, IL
Posted
May 15, 2026

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Job description

from Tempus careers

Passionate about precision medicine and advancing the healthcare industry?

Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time.

We're seeking a highly skilled and innovative Staff/Senior Machine Learning Engineer to join our Clinical AI Team. As a Staff/Senior Machine Learning Engineer, you'll play a crucial role in leveraging and deploying cutting-edge natural language processing models and LLMs specifically tailored for healthcare applications at scale. Your work will contribute to optimizing clinical workflows, improving clinical trial matching, and advancing medical research. This position offers an exciting opportunity to leverage the power of natural language processing and LLMs to revolutionize healthcare and make a significant impact on people's lives.

What You Will Do:

  • Build and operate production AI pipelines: LLM-powered extraction, batch orchestration, and inference, with a focus on reliability, cost, and latency

  • Design and maintain Airflow-based orchestration for batch clinical workflows

  • Build the observability (metrics, logging, alerting) that catches regressions before they reach downstream consumers

  • Build and maintain eval infrastructure that measures clinical model output quality continuously: regression detection, drift, gold-set management, dashboards

    This is an excerpt. Read the full job description on Tempus careers →
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