principal operations IT Engineer tech_leadership · Posted May 15, 2026
$114,700 – $212,900
USD per year

About this role

Genentech is hiring a principal-level IT Engineer in the operations function based in Holly Springs, NC. The posting calls out experience with Compliance, Data Analytics. Compensation is listed at $114,700–$212,900 per year.

Role
IT Engineer
Function
operations
Level
principal
Track
Tech leadership
Employment
Full-time
Location
Holly Springs, NC
Department
Regulatory & Quality
Posted
May 15, 2026

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Job description

from Genentech careers

The Position

Welcome to Holly Springs, North Carolina— home to Roche/Genentech's largest-ever investment: a $2B greenfield start-up where next-generation technology, high-performing teams and Operational Excellence converge to create the global standard for high-volume, highly-efficient Drug Product manufacturing. 

The facility's core is defined by Innovation - leveraging advanced automation, robotics, digital tools, real-time data analytics, and simple, streamlined processes to produce the highest quality medicines. This plant meets today’s demand for CVRM (Cardiovascular, Renal, and Metabolism) medicines and is scalable to grow with the portfolio, which focuses on next-generation metabolic medicines specifically targeting the global obesity epidemic and Type 2 diabetes.  This is a fast-paced, entrepreneurial environment with a high-level of accountability, with planned launch in 2028. 

Are you a problem-solver and change-agent who thrives in a Team environment, eager to tackle the most complex manufacturing challenges? If so, this is a once-in-a-lifetime opportunity to launch a state-of-the-art facility from the ground-up and shape the culture of our organization for the next generation. 

Join us in Holly Springs, where you won't just build a plant—you will build the future of medicine.

The Opportunity

This is an excerpt. Read the full job description on Genentech careers →
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