Senior Principal Engineer, Compounding, Dispensing, and Powder Handling
Genentech · Holly Springs, NC · Manufacturing & Engineering
About this role
Genentech is hiring a principal-level Principal Engineer in the software engineering function based in Holly Springs, NC. The posting calls out experience with API Development, Performance Optimization, Data Analytics. Compensation is listed at $114,400–$212,400 per year.
- Role
- Principal Engineer
- Function
- software engineering
- Level
- principal
- Track
- Tech leadership
- Employment
- Full-time
- Location
- Holly Springs, NC
- Department
- Manufacturing & Engineering
- Posted
- Apr 23, 2026
More roles at Genentech
Job description
from Genentech careersThe Position
Welcome to Holly Springs, North Carolina— home to Roche/Genentech's largest-ever investment: a $2B greenfield start-up where next-generation technology, high-performing teams and Operational Excellence converge to create the global standard for high-volume, highly-efficient Drug Product manufacturing.
The facility's core is defined by Innovation - leveraging advanced automation, robotics, digital tools, real-time data analytics, and simple, streamlined processes to produce the highest quality medicines. This plant meets today’s demand for CVRM (Cardiovascular, Renal, and Metabolism) medicines and is scalable to grow with the portfolio, which focuses on next-generation metabolic medicines specifically targeting the global obesity epidemic and Type 2 diabetes. This is a fast-paced, entrepreneurial environment with a high-level of accountability, with planned launch in 2028.
Are you a problem-solver and change-agent who thrives in a Team environment, eager to tackle the most complex manufacturing challenges? If so, this is a once-in-a-lifetime opportunity to launch a state-of-the-art facility from the ground-up and shape the culture of our organization for the next generation.
Join us in Holly Springs, where you won't just build a plant—you will build the future of medicine.
The Opportunity: