Principal Software Engineering Manager - Substrate efficiency

M365 Copilot inference is a high-impact engineering team advancing applied AI and large-scale machine learning across Microsoft. We design and operate the platform powering Microsoft 365 Copilot experiences, delivering intelligent capabilities to millions of users.

Our team owns one of the world’s largest AI inference platforms, operating at massive GPU scale across global datacenters. We build the core LLM API and routing services that enable low-latency, highly available AI experiences, and continuously push the boundaries of performance, scalability, and efficiency. 
We are hiring a Principal Software Engineering Manager to lead a strategic initiative focused on maximizing throughput per GPU across the Copilot inference stack. This role is to drive inference engine efficiency by optimizing model execution and runtime performance, improving throughput per GPU, reducing cost per query, and unlocking capacity without additional hardware investment.

Microsoft’s mission is to empower every person and every organization on the planet to achieve more. As employees we come together with a growth mindset, innovate to empower others, and collaborate to realize our shared goals. Each day we build on our values of respect, integrity, and accountability to create a culture of inclusion where everyone can thrive at work and beyond.

• Build and lead a high-performing engineering team focused on inference runtime efficiency and model execution performance.

• Define and drive strategy to improve throughput per GPU through runtime optimizations.

• Increase engineering agility, enabling faster experimentation, iteration, and rollout of performance improvements.

• Partner across M365 Core, AI Core, Azure, and Microsoft Research to co-design and productionize advanced inference optimizations.

• Establish metrics, telemetry, and experimentation frameworks to measure efficiency gains and guide investment decisions.

• Own live-site performance, reliability, and operational excellence for inference engines at scale.

• Drive alignment across partner teams on engine interfaces, performance goals, and optimization priorities.

• Bachelor's Degree in Computer Science or related technical field AND 8+ years technical engineering experience with coding in languages including, but not limited to, C, C++, C#, Java, JavaScript, or Python
  • OR equivalent experience.

Other Requirements:

Ability to meet Microsoft, customer and/or government security screening requirements are required for this role. These requirements include but are not limited to the following specialized security screenings:

• Microsoft Cloud Background Check: This position will be required to pass the Microsoft Cloud background check upon hire/transfer and every two years thereafter.