Principal Computational Scientist, Discovery Chemistry
Genentech · South San Francisco, CA · Research & Development
About this role
Genentech is hiring a principal-level Applied Scientist in the machine learning function based in South San Francisco, CA. The posting calls out experience with Automation, Python, Machine Learning, Cloud Computing. Compensation is listed at $144,900–$269,100 per year.
- Role
- Applied Scientist
- Function
- machine learning
- Level
- principal
- Track
- Individual contributor
- Employment
- Full-time
- Location
- South San Francisco, CA
- Department
- Research & Development
- Posted
- May 19, 2026
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Job description
from Genentech careersThe Position
The Opportunity
We are seeking an exceptional computational scientist to apply cutting-edge computational science, focussing on peptide therapeutic discovery. The ideal candidate will possess a unique blend of expertise in computational chemistry, including machine learning, to drive the advancement of our peptide hits to clinical candidates. This is a critical strategic role aimed at accelerating our discovery pipelines, optimizing our lead candidates, and unlocking the full potential of our experimental data.
Key Responsibilities
Advanced Modeling & Prediction: Lead the development and implementation of advanced computational methods (structure-based, physics-based) for target and peptide modeling and optimization. Implement machine learning models to accurately predict critical peptide properties such as solubility, permeability, stability, immunogenicity, and potency.
Platform Development: Contribute to the design, development, and deployment of a unified computational platform for peptide therapeutic discovery. Spearhead the creation of complex workflows and pipelines to enable the selection, design, and optimization of peptide modalities.
AI/ML for Drug Discovery: In collaboration with our internal AI for Drug Discovery team, apply advanced AI/ML technologies, including protein-ligand co-folding, generative and active learning models, to drive progress in drug discovery with a focus on therapeutic peptide design.
Provide strategic direction and present scientific findings to internal and external stakeholders, including wet-lab scientists.
This is an excerpt. Read the full job description on Genentech careers →