principal software engineering Principal Engineer tech_leadership · Posted Apr 17, 2026
$170,600 – $316,800
USD per year

About this role

Genentech is hiring a principal-level Principal Engineer in the software engineering function based in South San Francisco, CA. The posting calls out experience with System Design, Security, Automation. Compensation is listed at $170,600–$316,800 per year.

Role
Principal Engineer
Function
software engineering
Level
principal
Track
Tech leadership
Employment
Full-time
Location
South San Francisco, CA
Department
Business Strategy & Delivery
Posted
Apr 17, 2026

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Job description

from Genentech careers

The Position

Are you an innovative automation leader eager to revolutionize research facilities? Genentech is launching a new chapter with the creation of its Campus Development Team (CDT), tasked with turning the ambitious Campus Vision Plan for the South San Francisco campus into reality. We are seeking a dynamic Senior Principal Automation Project Manager to spearhead the integration and delivery of advanced control systems and intelligent building technologies within our cutting-edge laboratories and research environments. This is your opportunity to influence the future of life sciences infrastructure by driving automation initiatives that foster innovation, collaboration, and operational excellence.

At the forefront of our campus transformation, this role offers a unique chance to shape a highly automated, data-driven research hub. You will be responsible for implementing automation systems that support complex laboratory operations, autonomous building controls, and smart infrastructure, all aligned with our commitment to sustainability and digital innovation. If you are a strategic thinker with a passion for cutting-edge technology and a talent for leading cross-disciplinary teams, we invite you to join us in redefining the future of biotech innovation.

The Opportunity
The responsibilities for this position may include, but are not limited to:

  • Leading the end-to-end delivery of automation, controls, and smart building systems, serving as the single point of accountability for project success.

    This is an excerpt. Read the full job description on Genentech careers →
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